What are factor Xa inhibitors used for?
Factor Xa inhibitors are a type of anticoagulant (blood thinning drugs) that work by binding selectively and reversibly to the clotting factor Xa. Factor Xa plays a crucial role in the blood clotting mechanism when you get an injury by forming a mesh to prevent loss of blood.
When do you use factor Xa?
Coagulation factor Xa is used to treat uncontrolled bleeding in people who take the anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis). Coagulation factor Xa was approved by the US Food and Drug Administration (FDA) on an “accelerated” basis.
What are the indications for anticoagulants?
Anticoagulation is an important component of the management strategy for several common medical conditions. It is indicated for the prevention of recurrent thrombosis in patients with venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, and ischemic stroke.
What medications are factor Xa inhibitors?
Factor Xa Inhibitors
- apixaban.
- Arixtra.
- betrixaban.
- Bevyxxa.
- edoxaban.
- Eliquis.
- fondaparinux.
- rivaroxaban.
What is the role of factor Xa?
Factor Xa is a serine protease which cleaves prothrombin to generate thrombin and lies at the crossroads of the extrinsic and intrinsic coagulation pathway. Only a small amount of factor Xa is needed to generate many molecules of thrombin.
How does apixaban inhibit XA?
The factor Xa inhibitors that are currently commercially available include rivaroxaban, apixaban, betrixaban, and edoxaban. These drugs bind to factor Xa and prevent the formation of thrombin by interrupting the extrinsic and intrinsic coagulation cascades.
What are indications for blood thinners?
While there are many reasons why blood thinners are prescribed, the three most common indications for their use are:
- Prevention of stroke (clot in the brain)
- Prevention and treatment of venous thromboembolism (clot in a vein)
- Prevention of arterial thromboembolism (clot in an artery)
What are the indications for warfarin?
The three most common indications for warfarin therapy are; • atrial fibrillation (AF) • venous thromboemolism (VTE), and • prosthetic heart valves. Atrial fibrillation is probably the most common indication for warfarin therapy in our community.
Is factor Xa a prothrombin?
Factor Xa is the prime component of the prothrombinase complex which converts large amounts of prothrombin—the “thrombin burst”. Each molecule of Factor Xa can generate 1000 molecules of thrombin. This large burst of thrombin is responsible for fibrin polymerization to form a thrombus.
Who needs ELIQUIS?
ELIQUIS is a prescription medicine used to: reduce the risk of stroke and blood clots in people who have atrial fibrillation. reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.
What are the medical conditions associated with Factor Xa inhibitors?
Medical conditions associated with factor Xa inhibitors: Atrial Fibrillation. Coronary Artery Disease. Deep Vein Thrombosis. Deep Vein Thrombosis Prophylaxis after Abdominal Surgery. Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery. Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery.
Do factor Xa inhibitors prolong thromboplastin time?
Factor Xa inhibitors prolong the partial thromboplastin time (aPTT), prothrombin time (PT), and INR. The effect is small and highly variable making these studies of no practical value in monitoring the therapeutic effect of Factor Xa inhibitors.
What is the role of factor Xa in the treatment of embolism?
They are used for the treatment and prevention of deep vein thrombosis and acute pulmonary embolism, and to reduce the risk of stroke and embolism in people with nonvalvular atrial fibrillation. Factor Xa is generated by both the extrinsic and intrinsic coagulation pathways and is responsible for activating prothrombin to thrombin.
What are the contraindications for direct Xa inhibitors?
Direct Xa inhibitors are contraindicated in people who are actively bleeding or who are at high risk of bleeding. The effects on the unborn or newly born child are unknown, hence these drugs are not prescribed in pregnancy or breast feeding mothers.