Is ethyl cellulose hydrophilic?
Ethyl cellulose is also a nontoxic, inert hydrophobic polymer widely used in sustained release formulations and to control the dissolution rate of drugs (Quadir et al., 2005. Evaluation of ethylcellulose ss matrices for controled release drug delivery.
Is ethyl cellulose a liquid?
Ethyl cellulose (EC) is a partly O-ethylated cellulose ether derivative. It is available in a variety of grades, which differ in viscosity. EC is prepared by the reaction of ethyl chloride with alkali cellulose.
In which solvent ethyl cellulose is soluble?
Ethylcellulose containing 46- 48% or more of ethoxyl groups is freely soluble in ethanol, in methanol, in toluene, in chloroform, and in ethyl acetate. . A clear, stable, slightly yellow solution is formed.
Is cellulose soluble in ethanol?
Ethyl cellulose is soluble in varying amounts in certain organic solvents, depending upon the ethoxyl content. Ethylcellulose (containing 46- 48% or more of ethoxyl groups) is freely soluble in ethanol, methanol, toluene, chloroform, and ethyl acetate.
Which polymers are hydrophilic?
Hydrophilic polymers, such as polyacrylamide, polyurethanes, poly-(hydroxyethyl methacrylamide), or poly(ethylene glycol derivatives [e.g., Pluronic, a commercial poly(ethylene glycol)-co-poly-ethyleneoxide)] are used to create nanogels that can be doped with organic fluorescent dyes and drugs for simultaneous imaging …
Is ethyl cellulose pH dependent?
The system was designed utilizing a combination of hydrophilic polymer (polycarbophil or carbopol) with pH-dependent swelling property and hydrophobic polymer (ethyl cellulose) capable of imparting delayed release property.
Is ethyl cellulose soluble in ethanol?
Ethylcellulose containing 46- 48% or more of ethoxyl groups is freely soluble in ethanol, in methanol, in toluene, in chloroform, and in ethyl acetate.
Is cellulose soluble in water?
Cellulose is insoluble in water but can be dissolved in strong acidic or alkaline conditions.
Why cellulose is insoluble in water?
Like starches, cellulose is a polymer of glucose but the glucose monomers are connected with more chemical bonds than in starch. This makes cellulose very strong and insoluble in water, unlike starch. This is good because plants use cellulose for structure.
Is ethyl cellulose soluble or insoluble in water?
Therefore, ethyl cellulose is in the industry a typical cellulose ether soluble in organic solvents but insoluble in water. When the degree of substitution of ethyl is between 0.7 and 1.7, Ethyl Cellulose is soluble in water; while it is higher than 1 .5, it is soluble in organic solvents. The DS value of Ethyl Cellulose produced in the U.S.
What is ethethyl cellulose?
Ethyl cellulose (EC) is a partly O -ethylated cellulose ether derivative. It is available in a variety of grades, which differ in viscosity. EC is prepared by the reaction of ethyl chloride with alkali cellulose.
What is the DS value of ethyl cellulose?
The DS value of Ethyl Cellulose produced in the U.S. Is between 2.2-2.6. The product is soluble in the mixed solvent of hydrocarbon and a lower alcohol, ketones, and ethers with low molecular weight. Ethyl Cellulose is usually white or slightly yellow.
How do you use ethyl cellulose for granulation?
Granulations using ethyl cellulose result in softer granules, which compress into tablets that disintegrate easily. The dissolution of the active ingredient, however, can be retarded because EC is insoluble in water. EC can be used in the dry form or in a hydroalcoholic solution for wet granulation.