What is the concentration of atipamezole?
(atipamezole hydrochloride) Sterile Injectable Solution – 5.0 mg/mL.
What is ANTISEDAN?
ANTISEDAN (atipamezole) is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR ® (dexmedetomidine hydrochloride) and DEXDOMITOR ® 0.1 (dexmedetomidine hydrochloride).
What is the concentration of Dexdomitor?
Each mL of DEXDOMITOR contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s. INDICATIONS: DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facili- tate clinical examinations.
Can you overdose ANTISEDAN?
Signs of overdose were dose-related and consistent with those expected in non-sedated dogs having received a stimulant. Signs seen at elevated doses included excitement, panting, trembling, vomiting, soft or liquid feces or vasodilation (injection) of the sclera.
How do you calculate ANTISEDAN?
Although injection volumes are the same, the concentration of Antisedan (5.0 mg/mL) is 10 times that of Dexdomitor (0.5 mg/mL) and 5 times that of Domitor (1.0 mg/mL). Dogs that are sedated but ambulatory may be treated with Antisedan, if warranted. The dosage of Antisedan is calculated based upon body surface area.
What is the calculation for ANTISEDAN?
The molecular formula is C14H16N2 • HCl and structural formula is: Each mL of ANTISEDAN contains 5.0 mg atipamezole hydrochloride, 1.0 mg methylparaben (NF), 8.5 mg sodium chloride (USP), and water for injection (USP).
How do you calculate Antisedan?
What happens if Antisedan is given IV?
Atipamezole administered IV may result in rapid relaxation of vascular tone, which coupled with bradycardia could result in cardiovascular collapse.
How does Antisedan work?
Atipamezole is a potent alpha 2-antagonist which selectively and competitively inhibits alpha 2-adrenergic receptors. The result of atipamezole administration in the dog is the rapid recovery from the sedative and analgesic effects produced by the alpha 2-adrenergic agonists dexmedetomidine or medetomidine.
How do you convert mg/kg to mg m2?
To convert dose in mg/kg to mg/m2 of humans or animals is carried out using the Km factor in table1 as: mg/m2 = Km × (mg/kg) (Eq.
What is the volume of injection for Antisedan?
The concentration of Antisedan has been formulated such that the volume of injection is the same (mL for mL) as the recommended dose volume of Dexdomitor or Domitor, and may be given at any time following Dexdomitor or Domitor administration.
How many mg of atipamezole are in Antisedan?
Each mL of ANTISEDAN contains 5.0 mg atipamezole hydrochloride, 1.0 mg methylparaben (NF), 8.5 mg sodium chloride (USP), and water for injection (USP). ANTISEDAN is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR (dexmedetomidine hydrochloride), and DOMITOR (medetomidine hydrochloride) in dogs.
What is the chemical formula for Antisedan?
The molecular formula is C 14 H 16 N 2 • HCl and structural formula is: Each mL of ANTISEDAN contains 5.0 mg atipamezole hydrochloride, 1.0 mg methylparaben (NF), 8.5 mg sodium chloride (USP), and water for injection (USP).
What is Antisedan used for in dogs?
ANTISEDAN is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR (dexmedetomidine hydrochloride), and DOMITOR (medetomidine hydrochloride) in dogs. ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR.